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speed congenics  (Transnetyx)


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    Transnetyx speed congenics
    Speed Congenics, supplied by Transnetyx, used in various techniques. Bioz Stars score: 95/100, based on 37 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/speed congenics/product/Transnetyx
    Average 95 stars, based on 37 article reviews
    speed congenics - by Bioz Stars, 2026-06
    95/100 stars

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    To facilitate further characterisation and analysis the CB6 pups carrying the Chil3 deletion were backcrossed onto a BALB/c background. a strategy used to generate CB6 embryos for microinjection. b Speed congenics using the Transnetyx genetic monitoring service was then used to quantify the heterozygosity across each pup’s genome and the animals with the lowest heterozygosity was used for future breeding allowing completed transfer to the BALB/c background in five generations

    Journal: Transgenic Research

    Article Title: Generation of a Ym1 deficient mouse utilising CRISPR-Cas9 in CB6 embryos

    doi: 10.1007/s11248-025-00455-8

    Figure Lengend Snippet: To facilitate further characterisation and analysis the CB6 pups carrying the Chil3 deletion were backcrossed onto a BALB/c background. a strategy used to generate CB6 embryos for microinjection. b Speed congenics using the Transnetyx genetic monitoring service was then used to quantify the heterozygosity across each pup’s genome and the animals with the lowest heterozygosity was used for future breeding allowing completed transfer to the BALB/c background in five generations

    Article Snippet: Speed congenics utilises a panel of strain specific SNPs to identify the optimal animal to use for breeding (Fig. a) (Transnetyx speed congenic service) (Fahey et al. ; ‘The Importance of Monitoring Genetic Background in Genetically Modified Mouse Colonies’, Transnetyx White Paper; ‘Speed Congenics Efficiency, Economy, Stability, Consistency, and Transparency’, Transnetyx White Paper).

    Techniques: Microinjection